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PPI & Clopidogrel Interaction
  • Patients on omeprazole & esomeprazole
  • Patients on clopidogrel

Reasoning: In light of the most recent evidence, the previous advice on the concomitant use of clopidogrel with proton pump inhibitors has now been modified. Use of either omeprazole or esomeprazole with clopidogrel should be discouraged. The current evidence does not support extending this advice to other PPIs  

https://www.gov.uk/drug-safety-update/clopidogrel-and-proton-pump-inhibitors-interaction-updated-advice

 PPI & HIV medication 
  • Patients on Rilipvirine 
  • Patients on any PPI

Reasoning: Coadministration is contraindicated as significant decreases in rilpivirine plasma concentrations may occur

https://www.hiv-druginteractions.org/view_all_interactions/391341?co_drug_id=2171

 

 

 

 

 

 

 

 

 

 

PPI/HIV Interaction

  • Patients on PPIs
  • Patients on HIV medication

 

Omeprazole esomeprazole clopidogrel

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