• Orlistat works by blocking the enzymes in the stomach and intestines.
  • Fat is normally broken down by these enzymes and absorbed into your body to be stored.
  • Without these enzymes, 30 to 40 percent less dietary fat will be taken up by your body.
  • Instead, the unabsorbed fat will pass directly through your digestive system.


  • in conjunction with a mildly hypocaloric diet for the treatment of obese patients with a body mass index (BMI) greater or equal to 30 kg/m2
  • overweight patients (BMI ≥ 28 kg/m2) with associated risk factors

Initiation & Review

  1. Obtain patient's baseline weight and BMI and repeat at each review
  2. Reinforcement of adherence and lifestyle
  3. Ensure patient takes supplements - Vitamin A, D, E & K


  1. Recheck weight and BMI
  2. Has it decreased by 5% since initiation - Treatment with orlistat should be discontinued after 12 weeks if patients have been unable to lose at least 5 % of the body weight as measured at the start of therapy
  3. Is patient currently suffering with side effects
  4. Ensure patient takes supplements - Vitamin A, D, E & K
  5. Annual discussion around potential benefits and limitations with the patient, reinforcement of adherence and lifestyle

Reference sources:

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