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Long Term Effects of Z-Drugs


Long term effects of Z-Drugs

Muscle weakness, vertigo, effects on cognition including an increased risk of dementia.

These effects can lead to adverse clinical outcomes, such as an increased risk of falls and increased risk of motor vehicle accidents. Elderly patients have reduced clearance of medicines and are likely to require a lower dose to minimise adverse effects. Discontinuing the use of zopiclone or a benzodiazepine may reverse some of these effects, e.g. improving motor performance, cognition and reducing the risk of dementia. Concomitant use of benzodiazepines or zopiclone with opioids or alcohol increases many risks, such as lack of judgement, sexual disinhibition, criminal activity and fatal overdose.

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