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Benzodiazepines

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Benzodiazepine and Z drugs equivalence doses

Benzodiazepines1
Half-life (hrs)2
[active metabolite]
Approximately Equivalent
Oral dosages (mg)3
Alprazolam
(Xanax, Xanor, Tafil)
6-12
0.5
Chlordiazepoxide
(Librium)
5-30 [36-200]
25
Clobazam
(Frisium)5
12-60
20
Clonazepam
(Klonopin, Rivotril)5
18-50
0.5
Diazepam
(Valium)
20-100 [36-200]
10
Flunitrazepam
(Rohypnol)
18-26 [36-200]
1
Flurazepam
(Dalmane)
[40-250]
15-30
Lorazepam
(Ativan, Temesta, Tavor)
10-20
1
Lormetazepam
(Noctamid)
10-12
1-2
Nitrazepam
(Mogadon)
15-38
10
Oxazepam
(Serax, Serenid,
Serepax, Seresta)
4-15
20
Prazepam
(Centrax, Lysanxia)
[36-200]
10-20
Temazepam
(Restoril, Normison,
Euhypnos)
8-22
20
Zaleplon
(Sonata)
2
20
Zolpidem
(Ambien, Stilnoct, Stilnox)
2
20
Zopiclone
(Zimovane, Imovane)
5-6
15

 

Withdrawal from Diazepam

 
Morning
Night
Total
Daily Dosage
Starting dosage diazepam 20mg diazepam 20mg
40mg
Stage 1 (1-2 weeks) diazepam 18mg diazepam 20mg
38mg
Stage 2 (1-2 weeks) diazepam 18mg diazepam 18mg
36mg
Stage 3 (1-2 weeks) diazepam 16mg diazepam 18mg
34mg
Stage 4 (1-2 weeks) diazepam 16mg diazepam 16mg
32mg
Stage 5 (1-2 weeks) diazepam 14mg diazepam 16mg
30mg
Stage 6 (1-2 weeks) diazepam 14mg diazepam 14mg
28mg
Stage 7 (1-2 weeks) diazepam 12mg diazepam 14mg
26mg
Stage 8 (1-2 weeks) diazepam 12mg diazepam 12mg
24mg
Stage 9 (1-2 weeks) diazepam 10mg diazepam 12mg
22mg
Stage 10 (1-2 weeks) diazepam 10mg diazepam 10mg
20mg
Stage 11 (1-2 weeks) diazepam 8mg diazepam 10mg
18mg
Stage 12 (1-2 weeks) diazepam 8mg diazepam 8mg
16mg
Stage 13 (1-2 weeks) diazepam 6mg diazepam 8mg
14mg
Stage 14 (1-2 weeks) diazepam 5mg diazepam 8mg
13mg
Stage 15 (1-2 weeks) diazepam 4mg diazepam 8mg
12mg
Stage 16 (1-2 weeks) diazepam 3mg diazepam 8mg
11mg
Stage 17 (1-2 weeks) diazepam 2mg diazepam 8mg
10mg
Stage 18 (1-2 weeks) diazepam 1mg diazepam 8mg
9mg
Stage 19 (1-2 weeks)
--
 diazepam 8mg
8mg
Stage 20 (1-2 weeks)
--
 diazepam 7mg
7mg
Stage 21 (1-2 weeks)
--
 diazepam 6mg
6mg
Stage 22 (1-2 weeks)
--
 diazepam 5mg
5mg
Stage 23 (1-2 weeks)
--
 diazepam 4mg
4mg
Stage 24 (1-2 weeks)
--
 diazepam 3mg
3mg
Stage 25 (1-2 weeks)
--
 diazepam 2mg
2mg
Stage 26 (1-2 weeks)
--
 diazepam 1mg
1mg

Withdrawal from Alprazolam 

 
Morning
Midday/Afternoon
Evening/Night
Daily Diazepam
Equivalent
Starting dosage alprazolam 2mg alprazolam 2mg alprazolam 2mg
120mg
Stage 1
(one week)		 alprazolam 2mg alprazolam 2mg alprazolam 1.5mg
diazepam 10mg
120mg
Stage 2
(one week)		 alprazolam 2mg alprazolam 2mg alprazolam 1mg
diazepam 20mg
120mg
Stage 3
(one week)		 alprazolam 1.5mg
diazepam 10mg		 alprazolam 2mg alprazolam 1mg
diazepam 20mg
120mg
Stage 4
(one week)		 alprazolam 1mg
diazepam 20mg		 alprazolam 2mg alprazolam 1mg
diazepam 20mg
120mg
Stage 5
(1-2 weeks)		 alprazolam 1mg
diazepam 20mg		 alprazolam 1mg
diazepam 10mg		 alprazolam 1mg
diazepam 20mg
110mg
Stage 6
(1-2 weeks)		 alprazolam 1mg
diazepam 20mg		 alprazolam 1mg
diazepam 10mg		 alprazolam 0.5mg
diazepam 20mg
100mg
Stage 7
(1-2 weeks)		 alprazolam 1mg
diazepam 20mg		 alprazolam 1mg
diazepam 10mg		 Stop alprazolam
diazepam 20mg
90mg
Stage 8
(1-2 weeks)		 alprazolam 0.5mg
diazepam 20mg		 alprazolam 1mg
diazepam 10mg		 diazepam 20mg
80mg
Stage 9
(1-2 weeks)		 alprazolam 0.5mg
diazepam 20mg		 alprazolam 0.5mg
diazepam 10mg		 diazepam 20mg
80mg
Stage 10
(1-2 weeks)		 alprazolam 0.5mg
diazepam 20mg		 Stop alprazolam
diazepam 10mg		 diazepam 20mg
60mg
Stage 11
(1-2 weeks)		 Stop alprazolam
diazepam 20mg		 diazepam 10mg diazepam 20mg
50mg
Stage 12
(1-2 weeks)		 diazepam 25mg Stop midday dose;
divert 5mg each
to morning and
night doses		 diazepam 25mg
50mg
Stage 13
(1-2 weeks)		 diazepam 20mg
--
 diazepam 25mg
45mg
Stage 14
(1-2 weeks)		 diazepam 20mg
--
 diazepam 20mg
40mg
 

Withdrawal from Lorazepam

 
Morning
Midday/Afternoon
Evening/Night
Daily Diazepam
Equivalent
Starting dosage lorazepam 2mg lorazepam 2mg lorazepam 2mg
60mg
Stage 1
(one week)		 lorazepam 2mg lorazepam 2mg lorazepam 1mg
diazepam 10mg
60mg
Stage 2
(one week)		 lorazepam 1.5mg
diazepam 5mg		 lorazepam 2mg lorazepam 1mg
diazepam 10mg
60mg
Stage 3
(one week)		 lorazepam 1.5mg
diazepam 5mg		 lorazepam 2mg lorazepam 0.5mg
diazepam 15mg
60mg
Stage 4
(one week)		 lorazepam 1.5mg
diazepam 5mg		 lorazepam 1.5mg
diazepam 5mg		 lorazepam 0.5mg
diazepam 15mg
60mg
Stage 5
(1-2 weeks)		 lorazepam 1.5mg
diazepam 5mg		 lorazepam 1.5mg
diazepam 5mg		 Stop lorazepam
diazepam 20mg
60mg
Stage 6
(1-2 weeks)		 lorazepam 1mg
diazepam 5mg		 lorazepam 1.5mg
diazepam 5mg		 diazepam 20mg
55mg
Stage 7
(1-2 weeks)		 lorazepam 1mg
diazepam 5mg		 lorazepam 1mg
diazepam 5mg		 diazepam 20mg
50mg
Stage 8
(1-2 weeks)		 lorazepam 0.5mg
diazepam 5mg		 lorazepam 1mg
diazepam 5mg		 diazepam 20mg
45mg
Stage 9
(1-2 weeks)		 lorazepam 0.5mg
diazepam 5mg		 lorazepam 0.5mg
diazepam 5mg		 diazepam 20mg
40mg
Stage 10
(1-2 weeks)		 Stop lorazepam
diazepam 5mg		 lorazepam 0.5mg
diazepam 5mg		 diazepam 20mg
35mg
Stage 11
(1-2 weeks)		 diazepam 5mg Stop lorazepam
diazepam 5mg		 diazepam 20mg
30mg
Stage 12
(1-2 weeks)		 diazepam 5mg diazepam 5mg diazepam 18mg
28mg
Stage 13
(1-2 weeks)		 diazepam 5mg diazepam 5mg diazepam 16mg
26mg
Stage 14
(1-2 weeks)		 diazepam 5mg diazepam 5mg diazepam 14mg
24mg
Stage 15
(1-2 weeks)		 diazepam 5mg diazepam 5mg diazepam 12mg
22mg
Stage 16
(1-2 weeks)		 diazepam 5mg diazepam 5mg diazepam 10mg
20mg
Stage 17
(1-2 weeks)		 diazepam 5mg diazepam 4mg diazepam 10mg
19mg
Stage 18
(1-2 weeks)		 diazepam 4mg diazepam 4mg diazepam 10mg
18mg
Stage 19
(1-2 weeks)		 diazepam 4mg diazepam 3mg diazepam 10mg
17mg
Stage 20
(1-2 weeks)		 diazepam 3mg diazepam 3mg diazepam 10mg
16mg
Stage 21
(1-2 weeks)		 diazepam 3mg diazepam 2mg diazepam 10mg
15mg
Stage 22
(1-2 weeks)		 diazepam 2mg diazepam 2mg diazepam 10mg
14mg
Stage 23
(1-2 weeks)		 diazepam 2mg diazepam 1mg diazepam 10mg
13mg
Stage 24
(1-2 weeks)		 diazepam 1mg diazepam 1mg diazepam 10mg
12mg
Stage 25
(1-2 weeks)		 diazepam 1mg Stop diazepam diazepam 10mg
11mg
Stage 26
(1-2 weeks)		 Stop diazepam
--
 diazepam 10mg
10mg
Stage 27
(1-2 weeks)
--
--
 diazepam 9mg
9mg
Stage 28
(1-2 weeks)
--
--
 diazepam 8mg
8mg
Stage 29
(1-2 weeks)
--
--
 diazepam 7mg
7mg
Stage 30
(1-2 weeks)
--
--
 diazepam 6mg
6mg
Stage 31
(1-2 weeks)
--
--
 diazepam 5mg
5mg
Stage 32
(1-2 weeks)
--
--
 diazepam 4mg
4mg
Stage 33
(1-2 weeks)
--
--
 diazepam 3mg
3mg
Stage 34
(1-2 weeks)
--
--
 diazepam 2mg
2mg
Stage 35
(1-2 weeks)
--
--
 diazepam 1mg
1mg
Stage 36
--
--
 Stop diazepam
--

 

Withdrawal from Nitrazepam

 
Bed-time dose
Starting dosage nitrazepam 10mg
Stage 1 (1 week) nitrazepam 5mg
diazepam 5mg
Stage 2 (1 week) Stop nitrazepam
diazepam 10mg
Stage 3 (1-2 weeks) diazepam 9mg
Stage 4 (1-2 weeks) diazepam 8mg
Stage 5 (1-2 weeks) diazepam 7mg
Stage 6 (1-2 weeks) diazepam 6mg
Stage 7 (1-2 weeks) diazepam 5mg
Stage 8 (1-2 weeks) diazepam 4mg
Stage 9 (1-2 weeks) diazepam 3mg
Stage 10 (1-2 weeks) diazepam 2mg
Stage 11 (1-2 weeks) diazepam 1mg
Stage 12 Stop diazepam

Withdrawal from Clonazepam

 
Morning
Midday/Afternoon
Evening/Night
Daily Diazepam
Equivalent
Starting dosage clonazepam 0.5mg clonazepam 0.5mg clonazepam 0.5mg
30mg
Stage 1
(1 week)		 clonazepam 0.5mg clonazepam 0.5mg clonazepam 0.25mg
diazepam 5mg
30mg
Stage 2
(1 week)		 clonazepam 0.5mg clonazepam 0.5mg Stop clonazepam
diazepam 10mg
30mg
Stage 3
(1 week)		 clonazepam 0.25mg
diazepam 5mg		 clonazepam 0.5mg diazepam 10mg
30mg
Stage 4
(1 week)		 clonazepam 0.25mg
diazepam 5mg		 clonazepam 0.25mg
diazepam 5mg		 diazepam 10mg
30mg
Stage 5
(1 week)		 Stop clonazepam
diazepam 10mg		 clonazepam 0.25mg
diazepam 5mg		 diazepam 10mg
30mg
Stage 6
(1-2 weeks)		 diazepam 10mg Stop clonazepam
diazepam 8mg		 diazepam 10mg
28mg
Stage 7
(1-2 weeks)		 diazepam 10mg diazepam 6mg diazepam 10mg
26mg
Stage 8
(1-2 weeks)		 diazepam 10mg diazepam 4mg diazepam 10mg
24mg
Stage 9
(1-2 weeks)		 diazepam 10mg diazepam 2mg diazepam 10mg
22mg
Stage 10
(1-2 weeks)		 diazepam 10mg Stop diazepam diazepam 10mg
20mg
Stage 11
(1-2 weeks)		 diazepam 8mg
--
 diazepam 10mg
18mg
Stage 12
(1-2 weeks)		 diazepam 6mg
--
 diazepam 10mg
16mg
Stage 13
(1-2 weeks)		 diazepam 4mg
--
 diazepam 10mg
14mg
Stage 14
(1-2 weeks)		 diazepam 2mg
--
 diazepam 10mg
12mg
Stage 15
(1-2 weeks)		 Stop diazepam
--
 diazepam 10mg
10mg
Continue reducing remaining diazepam by 1 mg every 2 weeks (see Schedule 3 Stage 26)

Withdrawal from Temazepam

 
Night time
Equivalent diazepam dosage
Starting dosage temazepam 30mg
15mg
Stage 1 (1-2 weeks) temazepam 15mg
diazepam 7.5mg
15mg
Stage 2 (1-2 weeks) temazepam 7.5mg
diazepam 12mg
15.75mg
Stage 3 (1-2 weeks) Stop temazepam
diazepam 15mg
15mg
Stage 4 (1-2 weeks) diazepam 14mg
14mg
Stage 5 (1-2 weeks) diazepam 13mg
13mg
Stage 6 (1-2 weeks) diazepam 12mg
12mg
Stage 7 (1-2 weeks) diazepam 11mg
11mg
Stage 8 (1-2 weeks) diazepam 10mg
10mg
Stage 9 (1-2 weeks) diazepam 9mg
9mg
Stage 10 (1-2 weeks) diazepam 8mg
8mg
Stage 11 (1-2 weeks) diazepam 7mg
7mg
Stage 12 (1-2 weeks) diazepam 6mg
6mg
Stage 13 (1-2 weeks) diazepam 5mg
5mg
Stage 14 (1-2 weeks) diazepam 4mg
4mg
Stage 15 (1-2 weeks) diazepam 3mg
3mg
Stage 16 (1-2 weeks) diazepam 2mg
2mg
Stage 17 (1-2 weeks) diazepam 1mg
1mg
Stage 18 Stop diazepam

Withdrawal from Chlordiazepoxide 

 
Morning
Midday
Evening/Night
Starting dosage chlordiazepoxide 25mg chlordiazepoxide 25mg chlordiazepoxide 25mg
Stage 1
(1-2 weeks)		 chlordiazepoxide 25mg chlordiazepoxide 20mg chlordiazepoxide 25mg
Stage 2
(1-2 weeks)		 chlordiazepoxide 20mg chlordiazepoxide 20mg chlordiazepoxide 25mg
Stage 3
(1-2 weeks)		 chlordiazepoxide 20mg chlordiazepoxide 20mg chlordiazepoxide 20mg
Stage 4
(1-2 weeks)		 chlordiazepoxide 25mg chlordiazepoxide 5mg chlordiazepoxide 25mg
Stage 5
(1-2 weeks)		 chlordiazepoxide 25mg Stop chlordiazepoxide chlordiazepoxide 25mg
Stage 6
(1-2 weeks)		 chlordiazepoxide 20mg
--
 chlordiazepoxide 25mg
Stage 7
(1-2 weeks)		 chlordiazepoxide 20mg
--
 chlordiazepoxide 20mg
Stage 8
(1-2 weeks)		 chlordiazepoxide 15mg
--
 chlordiazepoxide 20mg
Stage 9
(1-2 weeks)		 chlordiazepoxide 15mg
--
 chlordiazepoxide 15mg
Stage 10
(1-2 weeks)		 chlordiazepoxide 10mg
--
 chlordiazepoxide 15mg
Stage 11
(1-2 weeks)		 chlordiazepoxide 10mg
--
 chlordiazepoxide 10mg
Stage 12
(1-2 weeks)		 chlordiazepoxide 5mg
--
 chlordiazepoxide 10mg
Stage 13
(1-2 weeks)		 chlordiazepoxide 5mg
--
 chlordiazepoxide 5mg
Stage 14
(1-2 weeks)		 chlordiazepoxide
2.5mg (½ tablet)
--
 chlordiazepoxide 5mg
Stage 15
(1-2 weeks)		 chlordiazepoxide
2.5mg (½ tablet)
--
 chlordiazepoxide
2.5mg (½ tablet)
Stage 16
(1-2 weeks)		 Stop chlordiazepoxide
--
 chlordiazepoxide
2.5mg (½ tablet)
Stage 17
--
--
 Stop chlordiazepoxide

 

Withdrawal from Zopiclone 

 
Night time
Daily Diazepam
Equivalent
Starting dosage zopiclone 15mg
10mg
Stage 1
(1 week)		 zopiclone 7.5mg
diazepam 5mg
10mg
Stage 2
(1 week)		 Stop zopiclone
diazepam 10mg
10mg
Stage 3 (1-2 weeks) diazepam 9mg
9mg
Stage 4 (1-2 weeks) diazepam 8mg
8mg
Then continue reducing diazepam by 1mg every 1-2 weeks

 

 

 

 

 

 

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