Low Molecular Weight Heparin (LMWH) & Fondaparinux - Quick points



  • They are used in the prevention of blood clots and treatment of DVT and PE and in the treatment of MI
  • Heparin is a naturally occurring polysaccharide that inhibits coagulation, the process that leads to thrombosis.
  • Natural heparin consists of molecular chains of varying lengths, or molecular weights.
  • LMWHs consist of only short chains of polysaccharide, thus LMWHs have a lower molecular weight
  • The effects of natural heparin are more unpredictable than LMWH
  • eg Tinzaparin (highest molecular weight) , Enoxaparin, Dalteparin (lowest)
  • Due to its renal clearance, LMWH is contraindicated in patients with kidney disease in whom unfractionated heparin can be used safely


  • First in a new class of antithrombotic agents
  • Inhibits thrombin generation by selectively inhibiting factor Xa
  • Chemically synthesized; this leads to batch-to-batch consistency and the absence of potential risk of contamination problems. 
  • Exhibits complete bioavailability by the subcutaneous route and is rapidly absorbed, reaching its maximum concentration approximately 2 h post dosing.
  • It has a terminal half-life of 13 to 21 h, permitting once-daily dosing.
  • Less individual dose adjustments, less monitoring, low potential for drug-drug interactions


Tinzaparin Enoxaparin Dalteparin Fondaparinux

© 2023 AskShilpa.com | WellBN Ltd

Press enter to search

If you are involved in the prescribing process, then AskShilpa has been created for you!

01273 772020
18-19 Western Rd, Hove BN3 1AE

Shilpa's Words

We love askshilpa.com